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KMID : 0350519950480030845
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Journal of Catholic Medical College
1995 Volume.48 No. 3 p.845 ~ p.854
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The Effect of recombinant Tissue Plasminogen Activator on the Intracerebral Hematomas in Experimental Cat Models
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Abstract
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Recent clinical studies have demonstrated that intracisternal administration of recombinant tissue plasminogen activator (rt-PA) can facilitate the normal clearing of blood from the subarachnoid space. Urokinase, a first generation fibrinolytic
agent,
has been used to liquefy such clots with some success. Therefore, recombinant tissue plssminogen activator, a second generation fibrinolytic drug that may be safer and more effective, was studied to evaluate its dosage to lyse clots in vitro and
reactivity in the brain parenchyme. Intracerebral hematomas were created by stereotactically injecting 2 ml of clotted autogenous blood into the brain parenchyme of total 28 anesthetized adult cats (weighting 3.8 to 4.1 kg). The control animals
(group
A) received 1 ml of normal saline injected into the clots and the experimental animals received each 0.1 mg of rt-PT (group B), 0.5 mg of rt-PA (group C) and 1 mg of rt-PA (group D) at 6 hours after the clot injection. All animals were sacrificed
at 24
hours postinjection.
@ES The results were as follows :
@EN 1. The amount of remained clots after lysing the hematomas were as follows : 1.80±0.17 ml in group A, 1.65±0.23 ml in group B. 0.61±0.37ml in group C and 0.52±0.34 in group D. The result indicated that hematomas in rt-PA tresed groups (C
&
D)
were lysed better than the control group (P<0.05).
2. At lest 0.5 mg of rt-PA shouldbe ? for the lysis of 2 ml ml of hematomas.
3. Lightmicroscopic examination ? histological evidence of damage or hemorrhage in tissue sections from each brain.
This study suggest that rt-PA may be ? and effectively employed for the lysis of intracerebral hematomas in animal model.
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KEYWORD
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